ProvigilProvigil Abuse Provigil and weight loss Provigil side effects

Provigil medication is basically the brand name for the generic analeptic drug Modafinil. With its use, there is increased release of monoamines, especially the catecholamines norepinephrine and dopamine, in the central nervous system. Modafinil is also known to elevate the hypothalamic histamine levels. This has led to a few researchers concluding that Modafil is actually an agent promoting wakefulness, unlike the general stimulants like amphetamine.


Before initiating the treatment for excessive sleepiness, careful attention should be paid to treating the underlying causes leading to the sleep disorders. Provigil should be used adjunctively with standard treatments for the underlying causes of excessive sleepiness. Thus if the sleep disorder is due to obstructive sleep apnea (OSA), maximum effort should be given for treating the condition of OSA with continuous positive airway pressure (CPAP), before starting with Provigil.


Provigil is recommended at 200 mg per day, which is to be administered once. For the treatment of narcolepsy and obstructive sleep apnea, Provigil should be administered once at the beginning of the day. Those patients with shift work sleep disorder should take Provigil about one hour before starting the work shift. Dosage of Provigil is dependent on your present medical condition, as well as the response to treatment. Though 400mg/per day single dose has been given with no significant adverse effects, there is no solid evidence to prove that the extra dose confers any additional benefit.

In rare cases, addiction to Provigil has been reported. You must not increase your dosage; consume the drug more often or for a longer duration than has been prescribed. Do stop taking Provigil when told by the doctor.

Provigil - things you should know

Provigil, in some cases may result in serious rash or allergic condition which may even require hospitalization and can also lead to fatality. If at any point of time while on Provigil, you develop hives, rash, sores, swelling and experience trouble breathing or swallowing, do discontinue the usage of Provigil and give a call to your doctor immediately or get yourself treated in the emergency department.

Provigil should never be administered to children. Provigil also should not be taken by patients having a history of allergic reaction to such drugs as NUVIGIL (armodafinil). Patients with past cases of allergic reactions to ingredients such as croscarmellose sodium, lactose, magnesium stearate, microcrystalline cellulose also should not be treated with Provigil. Patients with mitral valve prolapse or those with experience of syndrome associated with mitral valve prolapse also should not be given Provigil.

Probable side effects associated with Provigil

Common forms of side effects associated with Provigil include headache, nervousness, nausea, stuffy nose, back pain, diarrhea, anxiety, and dizziness as well as upset stomach. If you feel any of the symptoms like chest pain, anxiety, depression, hallucinations, suicidal tendencies, mania, psychosis, aggression or any other form of mental problems, stop taking the medicine right away and give a call to your doctor.

It is better to avoid driving or indulging in any dangerous activity while you are on the initial stages of your treatment with Provigil. Do avoid consuming alcohol while you are on Provigil.

Before you start on Provigil, you must inform your doctor of any past mental health disorder, heart problems, high blood pressure, kidney and liver problems, drug abuse, alcohol abuse or any addiction. Women should tell their doctor if they are pregnant, or are planning to conceive and if they are breastfeeding. A patient taking Provigil will have higher chances of getting pregnant if she is only on birth control pills. It is wise to use additional contraceptive methods when taking Provigil.

Other uses of Modafinil (Provigil)

Off-label uses of Modafinil include for treating fatigue and sedation in cases of depression, chronic fatigue syndrome, fibromyalgia, spastic cerebral palsy as well as Parkinson's disease. The use of this drug is known to cause mood uplifting in shift workers and also can help in dealing with jet-lag.

Research on Modafinil indicates that it can bring about appetite reduction and subsequent weight loss. Modafinil also works to improve excessive daytime fatigue associated with primary biliary cirrhosis. Modafnil has even been used in off-label experiments in people with post-chemotherapy cognitive impairment called "chemobrain". In a random study among normal and healthy individuals, Modafinil has been found to be effective in improving general alertness, along with mood.

Several countries militaries have also known to have taken interest in Modafinil. It is used instead of amphetamine - the medicine that had been traditionally used for combat situations, where the soldiers experience sleep deprivation.

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